Nitrazepam has actually been associated with serious hepatic Problems, comparable to other nitrobenzodiazepines. Nitrobenzodiazepines such as nitrazepam, nimetazepam, flunitrazepam, and clonazepam tend to be more toxic for the liver than other benzodiazepines as They may be metabolically activated by CYP3A4 which can lead to cytotoxicity.[thirty] C